The efficacy of Auto-T cells bearing a multispecific DARPin Auto for treating tumors with heterogeneous antigen expression was evaluated in vivo. Effects The monospecific anti-EGFR E01 DARPin conferred strong tumor regression versus EGFR+ targets that was comparable by having an anti-EGFR scFv Auto. Linking 3 different DARPins in tandem was feasibl
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